Article
M-Sec facilitates intercellular transmission of HIV-1 through multiple mechanisms.
Retrovirology - 10 Jul 2020
Lotfi Sameh, Nasser Hesham, Noyori Osamu, Hiyoshi Masateru, Takeuchi Hiroaki, Koyanagi Yoshio, Suzu Shinya
Abstract excerpt
BACKGROUND: HIV-1 promotes the formation of tunneling nanotubes (TNTs) that connect distant cells, aiding cell-to-cell viral transmission between macrophages. Our recent study suggests that the cellular protein M-Sec plays a role in these processes. However, the timing, mechanism, and to what extent M-Sec contributes to HIV-1 transmission is not fully understood, and the lack of a cell line model that mimics...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.