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Vitamin D receptor (VDR) gene polymorphism in Egyptian vitiligo patients.

Journal of cosmetic dermatology - 1 Mar 2021

Saudi Wael M, Swelam Mervat M, El-Barbary Rasha A H, Zakaria Lola, Gaber Dalia A

Abstract excerpt

BACKGROUND: Vitiligo is an autoimmune dermatological disorder, precipitated by genetic and nongenetic factors leading to destruction of epidermal melanocytes. In Egypt, it has a prevalence rate of 1.2%. Vitamin D has stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells. The consequences of polymorphisms in VDR have been previously studied for...

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PMID: 32648639
DOI: 10.1111/jocd.13606

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