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Article

Associations among two vitamin D receptor (VDR) gene polymorphisms (ApaI and TaqI) in acne vulgaris: A pilot susceptibility study.

Journal of cosmetic dermatology - 1 Aug 2019

Swelam Mervat M, El-Barbary Rasha A H, Saudi Wael M, Fathi Marwa S, Soliman Dina A, Abd Elrehem Heba H

Abstract excerpt

BACKGROUND: Acne vulgaris (AV) pathogenesis is multifactorial. Vitamin D (VitD) plays an important role in sebocytes' differentiation and function. Most VitD functions are mediated by the nuclear VitD receptor (VDR) following binding of its biologically active form (1,25 dihydroxyvitamin D3). Genetic variations in VDR gene may cause significant receptor dysfunction and have been found to be associated with many...

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PMID: 30220112
DOI: 10.1111/jocd.12781

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