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The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells

27 Jul 2015

Abstract excerpt

Among the identified thousands of circular RNAs (circRNA) in humans and animals, Cdr1as (also known as CiRS-7) was recently demonstrated to act as a powerful miR-7 sponge/inhibitor in developing midbrain of zebrafish, suggesting a novel mechanism for regulating microRNA functions. MiR-7 is abundantly expressed in islet cells, but overexpressing miR-7 in transgenic mouse β cells causes diabetes. Therefore, we...

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PMID: 26211738
DOI: 10.1038/srep12453

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