Article
Vav3 Mediates Pseudomonas aeruginosa Adhesion to the Cystic Fibrosis Airway Epithelium.
Cell reports - 7 Jul 2020
Badaoui Mehdi, Zoso Alice, Idris Tahir, Bacchetta Marc, Simonin Juliette, Lemeille Sylvain, Wehrle-Haller Bernhard, Chanson Marc
Abstract excerpt
Pseudomonas aeruginosa (Pa) represents the leading cause of airway infection in cystic fibrosis (CF). Early airways colonization can be explained by enhanced adhesion of Pa to the respiratory epithelium. RNA sequencing (RNA-seq) on fully differentiated primary cultures of airway epithelial cells from CF and non-CF donors predict that VAV3, β1 INTEGRIN, and FIBRONECTIN genes are significantly enriched in CF....
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