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Article

Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin.

The Journal of cell biology - 5 Aug 2002

Ding Jianqing, Liu Jia-Jia, Kowal Anthony S, Nardine Timothy, Bhattacharya Priyanka, Lee Arthur, Yang Yanmin

Abstract excerpt

Giant axonal neuropathy (GAN), an autosomal recessive disorder caused by mutations in GAN, is characterized cytopathologically by cytoskeletal abnormality. Based on its sequence, gigaxonin contains an NH2-terminal BTB domain followed by six kelch repeats, which are believed to be important for pr...

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Source

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Identifiers

PMID: 12147674
DOI: 10.1083/jcb.200202055
PMCID: PMC2173828

Genes

GAN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12147674-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin.PMID 12147674Read ↗

The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy.Semantic proximity Read ↗

Gigaxonin, mutated in Giant Axonal Neuropathy, interacts with TDP-43 and other RNA binding proteinsSemantic proximity Read ↗

The instability of the BTB-KELCH protein Gigaxonin causes Giant Axonal Neuropathy and constitutes a new penetrant and specific diagnostic test.Semantic proximity Read ↗

Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway.Semantic proximity Read ↗

Gigaxonin is associated with the Golgi and dimerises via its BTB domain.Semantic proximity Read ↗

Genotype-phenotype analysis in patients with giant axonal neuropathy (GAN).Semantic proximity Read ↗

Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation.Semantic proximity Read ↗

The Kelch 3 motif on gigaxonin mediates the interaction with NUDCD3 and regulates vimentin filament morphologySemantic proximity Read ↗

Clinical and molecular findings in patients with giant axonal neuropathy (GAN).Semantic proximity Read ↗

Loss of IVNS1ABP, a gigaxonin paralogue, leads to a progeroid neuropathy due to impaired proteostasisSemantic proximity Read ↗

Giant axonal neuropathy (GAN): Case report and two novel mutations in the gigaxonin geneSemantic proximity Read ↗

Giant axonal neuropathy.Semantic proximity Read ↗

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