Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PNPLA3 gene polymorphism is associated with liver steatosis in children with Down syndrome.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 28 Aug 2020

Valentini Diletta, Mosca Antonella, Di Camillo Chiara, Crudele Annalisa, Sartorelli Maria Rita, Scoppola Vittorio, Tarani Luigi, Villani Alberto, Raponi Massimiliano, Novelli Antonio, Alisi Anna

Abstract excerpt

BACKGROUND AND AIMS: We previously demonstrated that children with Down syndrome (DS) exhibited a greater risk of steatosis than the general pediatric population. This trend was independent of obese phenotype, thus suggesting a role of genetic predisposition. Therefore, we investigated the prevalence of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) in function of genetic susceptibility...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiponectin
Share to Blood Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down Syndrome

Share to Interleukin-6

Share to Lipase

Share to Lipids

Share to Metabolic Syndrome

Share to Non-alcoholic Fatty Liver Disease

Source

Identifiers

PMID: 32636123
DOI: 10.1016/j.numecd.2020.05.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PNPLA3 gene polymorphism is associated with liver steatosis in children with Down syndrome.PMID 32636123Read ↗

Effect of the patatin-like phospholipase domain containing 3 gene (PNPLA3) I148M polymorphism on the risk and severity of nonalcoholic fatty liver disease and metabolic syndromes: A meta-analysis of paediatric and adolescent individuals.Semantic proximity Read ↗

Pediatric fatty liver disease: role of ethnicity and genetics.Semantic proximity Read ↗

Association of PNPLA3 rs738409 G/C gene polymorphism with nonalcoholic fatty liver disease in children: a meta-analysis.Semantic proximity Read ↗

Association of PNPLA3 rs738409 G/C gene polymorphism with nonalcoholic fatty liver disease in children: a meta-analysisSemantic proximity Read ↗

Effects of PNPLA3, TM6SF2 and SAMM50 on the development and severity of non-alcoholic fatty liver disease in children.Semantic proximity Read ↗

Influence of genetics on clinical trajectories in children with MASLD: role of the PNPLA3 I148M polymorphism.Semantic proximity Read ↗

A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents.Semantic proximity Read ↗

I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease.Semantic proximity Read ↗

Genetic variation and elevated liver enzymes during childhood, adolescence and early adulthood.Semantic proximity Read ↗

Ferritin and Liver Steatosis in Children: Interactions Between Metabolic Clustering and PNPLA3 Variants.Semantic proximity Read ↗

Non-alcoholic fatty liver disease and metabolic syndrome in adolescents: pathogenetic role of genetic background and intrauterine environment.Semantic proximity Read ↗

NAFLD and renal function in children: is there a genetic link?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.