Article
The contribution of serine 194 phosphorylation to steroidogenic acute regulatory protein function.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 2014
Sasaki Goro, Zubair Mohamad, Ishii Tomohiro, Mitsui Toshikatsu, Hasegawa Tomonobu, Auchus Richard J
Abstract excerpt
The steroidogenic acute regulatory protein (StAR) facilitates the delivery of cholesterol to the inner mitochondrial membrane, where the cholesterol side-chain cleavage enzyme catalyzes the initial step of steroid hormone biosynthesis. StAR was initially identified in adrenocortical cells as a phosphoprotein, the expression and phosphorylation of which were stimulated by corticotropin. A number of in vitro...
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