Article
A Pilot Study of Noninvasive Prenatal Diagnosis of Alpha- and Beta-Thalassemia with Target Capture Sequencing of Cell-Free Fetal DNA in Maternal Blood.
Genetic testing and molecular biomarkers - 1 Jul 2017
Wang Wenjuan, Yuan Yuan, Zheng Haiqing, Wang Yaoshen, Zeng Dan, Yang Yihua, Yi Xin, Xia Yang, Zhu Chunjiang
Abstract excerpt
AIMS: Thalassemia is a dangerous hematolytic genetic disease. In south China, ∼24% Chinese carry alpha-thalassemia or beta-thalassemia gene mutations. Given the fact that the invasive sampling procedures can only be performed by professionals in experienced centers, it may increase the risk of miscarriage or infection. Thus, most people are worried about the invasive operation. As such, a noninvasive and accurate...
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