[Prospective clinical study on non-invasive prenatal testing for severe thalassemia using tag-labeled targeted capture sequencing combined with a modified Bayesian model].

Abstract excerpt

Objective: To evaluate the clinical performance of a non-invasive prenatal testing (NIPT) approach for fetal severe thalassemia based on tag-labeled targeted capture sequencing combined with a modified Bayesian model (referred to as noninvasive thalassemia testing). Methods: This study was a prospective cohort study involving 452 couples of the Southeast Asian deletion (SEA) type α-thalassemia carriers who were...

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