Article
Design, synthesis and biological evaluation of 4-aniline quinazoline derivatives conjugated with hydrogen sulfide (H2S) donors as potent EGFR inhibitors against L858R resistance mutation.
European journal of medicinal chemistry - 15 Sept 2020
Zheng You-Guang, Zhang Wu-Qi, Meng Long, Wu Xiao-Qing, Zhang Ling, An Lin, Li Cheng-Lin, Gao Cai-Yun, Xu Liang, Liu Yi
Abstract excerpt
In this study, a series of 4-aniline quinazoline derivatives bearing hydrogen sulfide (H2S) donors were designed, synthesized and evaluated for biological activities. The synthesized compounds were screened for the enzymatic activities against EGFR and EGFR mutants by kinase target-based cell screening method. The results demonstrate that most compounds exhibit selectively inhibitory activities against...
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