Article
Impact of DPYD, DPYS, and UPB1 gene variations on severe drug-related toxicity in patients with cancer.
Cancer science - 1 Sept 2020
Yokoi Katsuyuki, Nakajima Yoko, Matsuoka Hiroshi, Shinkai Yasuko, Ishihara Takuma, Maeda Yasuhiro, Kato Takema, Katsuno Hidetoshi, Masumori Koji, Kawada Kenji, Yoshikawa Tetsushi, Ito Tetsuya, Kurahashi Hiroki
Abstract excerpt
Cancer treatment with a fluoropyrimidine (FP) is often accompanied by severe toxicity that may be dependent on the activity of catalytic enzymes encoded by the DPYD, DPYS, and UPB1 genes. Genotype-guided dose individualization of FP therapy has been proposed in western countries, but our knowledge of the relevant genetic variants in East Asian populations is presently limited. To investigate the association...
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