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Article

Focal Leptomeningeal Disease with Perivascular Invasion in EGFR-Mutant Non-Small-Cell Lung Cancer.

AJNR. American journal of neuroradiology - 1 Aug 2020

Dasgupta A, Moraes F Y, Rawal S, Diamandis P, Shultz D B

Abstract excerpt

We report a previously undescribed pattern of brain metastases in patients with epidermal growth factor receptor-mutated non-small-cell lung cancer treated with tyrosine kinase inhibitors and radiation therapy. These highly distinct lesions appear to spread focally within the leptomeninges, with invasion along the perivascular spaces (FLIP). The survival of patients with FLIP was significantly better compared...

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Identifiers

PMID: 32616581
DOI: 10.3174/ajnr.A6640
PMCID: PMC7658871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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