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[Correlations of Methylenetetrahydrofolate Reductase Gene Polymorphism and Genomic DNA Hypomethylation Level with Ankylosing Spondylitis].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae - 30 Jun 2020

Mao Ni, Chen Jinwei, Wang Jia, Xie Xi, Li Fen, Liu Yiming

Abstract excerpt

Objective To investigate the relationship of both DNA methylation level and methylenetrahydrofolate reductase(MTHFR)gene polymorphism with ankylosing spondylitis(AS). Methods Totally 200 Chinese AS patients with HLA-B27(+)and 120 healthy controls were included from Hunan Province.All the cases were diagnosed according to the 1984 modified New York criteria for AS.The DNA methylation was examined by cytosine...

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PMID: 32616124
DOI: 10.3881/j.issn.1000-503X.11516

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