Article
DNA damage analysis concerning GSTM1 and GSTT1 gene polymorphism in gold jewellery workers from Peshawar Pakistan.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Sept 2020
Khisroon Muhammad, Khan Ajmal, Ayub Asma, Ullah Ihsan, Farooqi Javeed, Ullah Abid
Abstract excerpt
PURPOSE: To evaluate the genotoxic effects of gold jewellery fumes and its association with GSTM1 and GSTT1 genetic polymorphisms. MATERIALS AND METHODS: We examined 94 subjects including 54 gold jewellery workers and 40 controls. The DNA damage was evaluated by alkaline comet assay and genotyping by PCR. RESULTS: The mean total comet score (TCS) in gold jewellery workers was significantly higher as compared to...
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