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Assessment of genotoxic and molecular mechanisms of cancer risk in smoking and smokeless tobacco users.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jun 2014

Chandirasekar R, Kumar B Lakshman, Sasikala K, Jayakumar R, Suresh K, Venkatesan R, Jacob Raichel, Krishnapriya E K, Kavitha H, Ganesh G Karthik

Abstract excerpt

Inexpensive forms of tobacco are widely used in developing countries such as India. We have evaluated genotoxicity endpoints (chromosome aberrations, micronucleus frequency, comet assay) and polymorphisms of the XRCC1 and p53 genes among smokers and smokeless tobacco (SLT) users in rural Tamilnadu, South India. Cytogenetic, DNA damage and SNP analyses were performed on peripheral blood samples; micronucleus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24769293
DOI: 10.1016/j.mrgentox.2014.04.007

Genes

XRCC1

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