mycoCSM: Using Graph-Based Signatures to Identify Safe Potent Hits against Mycobacteria

Abstract excerpt

Development of new potent, safe drugs to treat Mycobacteria has proven to be challenging, with limited hit rates of initial screens restricting subsequent development efforts. Despite significant efforts and the evolution of quantitative structure-activity relationship as well as machine learning-based models for computationally predicting molecule bioactivity, there is an unmet need for efficient and reliable...

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