Targeted Mass Spectrometry of a Clinically Relevant PSA Variant from Post-DRE Urines for Quantitation and Genotype Determination.

doi:10.1002/prca.202000012

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Article

Targeted Mass Spectrometry of a Clinically Relevant PSA Variant from Post-DRE Urines for Quantitation and Genotype Determination.

Proteomics. Clinical applications - 1 Nov 2020

Otto Joseph J, Correll Vanessa L, Engstroem Hampus A, Hitefield Naomi L, Main Brian P, Albracht Brenna, Johnson-Pais Teresa, Yang Li Fang, Liss Michael, Boutros Paul C, Kislinger Thomas, Leach Robin J, Semmes Oliver J, Nyalwidhe Julius O

Abstract excerpt

PURPOSE: The rs17632542 single nucleotide polymorphism (SNP) results in lower serum prostate specific antigen (PSA) levels which may further mitigate against its clinical utility as a prostate cancer biomarker. Post-digital rectal exam (post-DRE) urine is a minimally invasive fluid that is currently utilized in prostate cancer diagnosis. To detect and quantitate the variant protein in urine. EXPERIMENTAL DESIGN:...

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PMID: 32614141
DOI: 10.1002/prca.202000012
PMCID: PMC7674190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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