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Article

Transient AdeABC-mediated eravacycline resistance in carbapenem-resistant Acinetobacter baumannii ST2: a mutation-independent efflux pump adaptation.

Annals of clinical microbiology and antimicrobials - 12 Jan 2026

Yang Xu, He Nanhao, Haque Anwarul, Mai Ying, Wang Jiong, Xiao Shunian, Zhuo Chao

Abstract excerpt

PURPOSE: This study evaluated the impact of sub-MIC eravacycline exposure on carbapenem-resistant Acinetobacter baumannii with tigecycline MIC ≥ 8 µg/mL in clinical laboratory testing, and analyzed the resistance mechanisms. METHODS: 2144 A. baumannii isolates (2021–2024) from a Chinese tertiary hospital were analyzed for resistance trends. For 43 strains with tigecycline MIC ≥ 8 µg/mL, we conducted: (i) in vitro...

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Identifiers

PMID: 41526909
DOI: 10.1186/s12941-025-00847-y
PMCID: PMC12888453

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