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Transient AdeABC-mediated eravacycline resistance in carbapenem-resistant Acinetobacter baumannii ST2: a mutation-independent efflux pump adaptation.

Annals of clinical microbiology and antimicrobials - 12 Jan 2026

Yang Xu, He Nanhao, Haque Anwarul, Mai Ying, Wang Jiong, Xiao Shunian, Zhuo Chao

Abstract excerpt

PURPOSE: This study evaluated the impact of sub-MIC eravacycline exposure on carbapenem-resistant Acinetobacter baumannii with tigecycline MIC ≥ 8 µg/mL in clinical laboratory testing, and analyzed the resistance mechanisms. METHODS: 2144 A. baumannii isolates (2021–2024) from a Chinese tertiary hospital were analyzed for resistance trends. For 43 strains with tigecycline MIC ≥ 8 µg/mL, we conducted: (i) in vitro...

Topics

Acinetobacter baumannii
Anti-Bacterial Agents
Microbial Sensitivity Tests
Carbapenems
Humans
Membrane Transport Proteins
Tigecycline
Tetracyclines
Mutation
Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Resistance, Multiple, Bacterial

Acinetobacter Infections

Polymyxin B

Drug Resistance, Bacterial

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Identifiers

PMID: 41526909
DOI: 10.1186/s12941-025-00847-y
PMCID: PMC12888453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Transient AdeABC-mediated eravacycline resistance in carbapenem-resistant Acinetobacter baumannii ST2: a mutation-independent efflux pump adaptation.PMID 41526909Read ↗

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