Article
Genome-Wide Association Study of the Postprandial Triglyceride Response Yields Common Genetic Variation in LIPC (Hepatic Lipase).
Circulation. Genomic and precision medicine - 1 Aug 2020
Ibi Dorina, Noordam Raymond, van Klinken Jan Bert, Li-Gao Ruifang, de Mutsert Renée, Trompet Stella, Christen Tim, Blauw Lisanne L, van Heemst Diana, Mook-Kanamori Dennis O, Rosendaal Frits R, Jukema J Wouter, Dollé Martijn E T, Rensen Patrick C N, van Dijk Ko Willems
Abstract excerpt
BACKGROUND: The increase in serum triglyceride (TG) concentrations in response to a meal is considered a risk factor for cardiovascular disease. We aimed to elucidate the genetics of the postprandial TG response through genome-wide association studies (GWAS). METHODS: Participants of the NEO (Netherlands Epidemiology of Obesity) study (n=5630) consumed a liquid mixed meal after an overnight fast. GWAS of fasting...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.