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Article

Impact of LEDGIN treatment during virus production on residual HIV-1 transcription

2 Apr 2019

Abstract excerpt

BACKGROUND: Persistence of latent, replication-competent provirus is the main impediment towards the cure of HIV infection. One of the critical questions concerning HIV latency is the role of integration site selection in HIV expression. Inhibition of the interaction between HIV integrase and its chromatin tethering cofactor LEDGF/p75 is known to reduce integration and to retarget residual provirus to regions...

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PMID: 30940165
DOI: 10.1186/s12977-019-0472-3

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