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Article

A SNP of miR-146a is involved in bladder cancer relapse by affecting the function of bladder cancer stem cells via the miR-146a signallings.

Journal of cellular and molecular medicine - 1 Aug 2020

Wang Tianen, Yang Yanfeng, Wang Zhiyong, Zhang Xuechong, Li Dongsheng, Wei Jinxing

Abstract excerpt

MiR-146a-5p in urine samples was recently reported to be possibly used as a prognostic marker for bladder cancer (BC). Interestingly, YAP1 and COX2 were both demonstrated to function as stem cell regulators in BC. Therefore, in this study, we aimed to establish the molecular mechanism underlying the role of miR-146a, YAP1 and COX2 in BC relapse. We also studied the possibility of using the C > G genotype of...

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PMID: 32596945
DOI: 10.1111/jcmm.15480
PMCID: PMC7412697

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