Article
Human Fibrosis: Is There Evidence for a Genetic Predisposition in Musculoskeletal Tissues?
The Journal of arthroplasty - 1 Nov 2020
Dagneaux Louis, Owen Aaron R, Bettencourt Jacob W, Barlow Jonathan D, Amadio Peter C, Kocher Jean P, Morrey Mark E, Sanchez-Sotelo Joaquin, Berry Daniel J, van Wijnen Andre J, Abdel Matthew P
Abstract excerpt
BACKGROUND: Pathologic fibrosis is characterized by dysregulation of gene expression with excessive extracellular matrix production. The genetic basis for solid organ fibrosis is well described in the literature. However, there is a paucity of evidence for similar processes in the musculoskeletal (MSK) system. The purpose of this review is to provide an overview of existing evidence of genetic predisposition to...
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