Article
Quantitative and qualitative impairments in dendritic cell subsets of patients with ovarian or prostate cancer.
European journal of cancer (Oxford, England : 1990) - 1 Aug 2020
Mastelic-Gavillet Beatris, Sarivalasis Apostolos, Lozano Leyder Elena, Wyss Tania, Inoges Susana, de Vries Ingrid Jolanda Monique, Dartiguenave Florence, Jichlinski Patrice, Derrè Laurent, Coukos George, Melero Ignacio, Harari Alexandre, Romero Pedro, Viganó Selena, Kandalaft Lana Elias
Abstract excerpt
BACKGROUND: Dendritic cells (DCs) are the most efficient antigen-presenting cells, hence initiating a potent and cancer-specific immune response. This ability (mainly using monocyte-derived DCs) has been exploited in vaccination strategies for decades with limited clinical efficacy. Another alternative would be the use of conventional DCs (cDCs) of which at least three subsets circulate in human blood: cDC1s...
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