Article
Variation in RARG increases susceptibility to doxorubicin-induced cardiotoxicity in patient specific induced pluripotent stem cell-derived cardiomyocytes.
Scientific reports - 25 Jun 2020
Christidi Effimia, Huang Haojun, Shafaattalab Sanam, Maillet Agnes, Lin Eric, Huang Kate, Laksman Zachary, Davis Margot K, Tibbits Glen F, Brunham Liam R
Abstract excerpt
Doxorubicin is a potent anticancer drug used to treat a variety of cancer types. However, its use is limited by doxorubicin-induced cardiotoxicity (DIC). A missense variant in the RARG gene (S427L; rs2229774) has been implicated in susceptibility to DIC in a genome wide association study. The goal of this study was to investigate the functional role of this RARG variant in DIC. We used induced pluripotent stem...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.