Article
Variants in ADRB1 and CYP2C9: Association with Response to Atenolol and Losartan in Marfan Syndrome.
The Journal of pediatrics - 1 Jul 2020
Van Driest Sara L, Sleeper Lynn A, Gelb Bruce D, Morris Shaine A, Dietz Harry C, Forbus Geoffrey A, Goldmuntz Elizabeth, Hoskoppal Arvind, James Jeanne, Lee Teresa M, Levine Jami C, Li Jennifer S, Loeys Bart L, Markham Larry W, Meester Josephina A N, Mital Seema, Mosley Jonathan D, Olson Aaron K, Renard Marjolijn, Shaffer Christian M, Sharkey Angela, Young Luciana, Lacro Ronald V, Roden Dan M
Abstract excerpt
OBJECTIVE: To test whether variants in ADRB1 and CYP2C9 genes identify subgroups of individuals with differential response to treatment for Marfan syndrome through analysis of data from a large, randomized trial. STUDY DESIGN: In a subset of 250 white, non-Hispanic participants with Marfan syndrome in a prior randomized trial of atenolol vs losartan, the common variants rs1801252 and rs1801253 in ADRB1 and...
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