Article
A combination of the HLA-DRB1*03 phenotype and low plasma mannose-binding lectin predisposes to autoantibody formation in women with recurrent pregnancy loss.
Frontiers in immunology - 1 Jan 2023
Nørgaard-Pedersen Caroline, Steffensen Rudi, Kesmodel Ulrik Schiøler, Christiansen Ole Bjarne
Abstract excerpt
Introduction: It is documented that a series of autoantibodies can be detected with increased frequency in women with recurrent pregnancy loss (RPL) and they may impact the pregnancy prognosis negatively. It is unknown whether the autoantibodies per se or the basic immune disturbances underlying autoantibody production, are the reason for this association. Our group has previously found that some genetically...
Topics
- Female
- Humans
- Pregnancy
- Abortion, Habitual
- Antibodies, Antinuclear
- Autoantibodies
- HLA-DRB1 Chains
- Mannose-Binding Lectins
- Phenotype