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Up-regulated cytotrophoblast DOCK4 contributes to over-invasion in placenta accreta spectrum

23 Jun 2020

Abstract excerpt

Significance The syndrome of cytotrophoblast invasion beyond the normal boundary (in the superficial myometrium) is collectively termed placenta accreta spectrum. The incidence of this condition is rising. However, little is known about the underlying molecular changes. Global transcriptomic profiling of cytotrophoblasts isolated from these cases, as compared to gestational age-matched controls, revealed numerous...

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PMID: 32576693
DOI: 10.1073/pnas.1920776117

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