Article
Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia.
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia - 1 Aug 2020
Sandrim Valeria Cristina, Luizon Marcelo Rizzatti, Pilan Eliane, Caldeira-Dias Mayara, Coeli-Lacchini Fernanda Borchers, Kors Georgia, Berndt Iuly, Lacchini Riccardo, Cavalli Ricardo Carvalho
Abstract excerpt
OBJECTIVE: We examined the interaction of polymorphisms in the genes heme oxygenase-1 (HMOX1) and nitric oxide synthase (NOS3) in patients with preeclampsia (PE) as well as the responsiveness to methyldopa and to total antihypertensive therapy. METHODS: The genes HMOX1 (rs2071746, A/T) and NOS3 (rs1799983, G/T) were genotyped using TaqMan allele discrimination assays (Applied Biosystems, Foster City, CA, USA ),...
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