Article
A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice.
EBioMedicine - 1 Jul 2020
Kuang Yuanyuan, Zorzi Veronica, Buratto Damiano, Ziraldo Gaia, Mazzarda Flavia, Peres Chiara, Nardin Chiara, Salvatore Anna Maria, Chiani Francesco, Scavizzi Ferdinando, Raspa Marcello, Qiang Min, Chu Youjun, Shi Xiaojie, Li Yu, Liu Lili, Shi Yaru, Zonta Francesco, Yang Guang, Lerner Richard A, Mammano Fabio
Abstract excerpt
BACKGROUND: Numerous currently incurable human diseases have been causally linked to mutations in connexin (Cx) genes. In several instances, pathological mutations generate abnormally active Cx hemichannels, referred to also as "leaky" hemichannels. The goal of this study was to assay the in vivo efficacy of a potent antagonist antibody targeting Cx hemichannels. METHODS: We employed the antibody to treat...
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