Article
High levels of immunoglobulin expression predict shorter overall survival in patients with acute myeloid leukemia.
European journal of haematology - 1 Oct 2020
Wu Lina, Xia Miaoran, Sun Xiaoping, Han Xin, Zu Youli, Jabbour Elias J, You M James, Lin Pei, Li Shaoying, Xu Jie, Han Haibo, Bueso-Ramos Carlos E, Medeiros L Jeffrey, Qiu Xiaoyan, Yin C Cameron
Abstract excerpt
OBJECTIVES: It has been believed that immunoglobulins can only be produced by B lymphocytes and plasma cells. We have previously reported that IgG can be expressed in myeloblasts from patients with acute myeloid leukemia (AML) and plays a role in the proliferation and apoptosis of leukemic cells. However, its clinical impact has not been assessed. METHODS: We assessed the expression of different classes of...
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