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Functional genetic variants in centrosome-related genes CEP72 and YWHAG confer susceptibility to gastric cancer.

Archives of toxicology - 1 Aug 2020

Ni Jing, Wang Jinchen, Fu Yao, Yan Caiwang, Zhu Meng, Jiang Yue, Chen Jiaping, Ding Yanbing, Fan Xiangshan, Li Gang, Jin Guangfu

Abstract excerpt

Structural and numeric centrosome aberrations can induce chromosome segregation errors and promote tumor development and progression. We systematically evaluated associations of 19,603 single nucleotide polymorphisms (SNPs) across 136 centrosome-related genes with gastric cancer (GC) risk using four GWAS datasets with a total of 3771 cases and 5426 controls. We identified two loci at 15p13.3 and 7q11.23...

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PMID: 32535685
DOI: 10.1007/s00204-020-02782-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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