Article
Perivascular Stem Cell-Derived Cyclophilin A Improves Uterine Environment with Asherman's Syndrome via HIF1α-Dependent Angiogenesis.
Molecular therapy : the journal of the American Society of Gene Therapy - 5 Aug 2020
Park Mira, Hong Seok-Ho, Park So Hee, Kim Yeon Sun, Yang Seung Chel, Kim Hye-Ryun, Noh Songmi, Na Sunghun, Lee Hyung Keun, Lim Hyunjung J, Lyu Sang Woo, Song Haengseok
Abstract excerpt
Asherman's syndrome (AS) is characterized by intrauterine adhesions or fibrosis resulting from scarring inside the endometrium. AS is associated with infertility, recurrent miscarriage, and placental abnormalities. Although mesenchymal stem cells show therapeutic promise for the treatment of AS, the molecular mechanisms underlying its pathophysiology remain unclear. We ascertained that mice with AS, like human...
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