Article
Rice ORMDL controls sphingolipid homeostasis affecting fertility resulting from abnormal pollen development.
PloS one - 1 Jan 2014
Chueasiri Chutharat, Chunthong Ketsuwan, Pitnjam Keasinee, Chakhonkaen Sriprapai, Sangarwut Numphet, Sangsawang Kanidta, Suksangpanomrung Malinee, Michaelson Louise V, Napier Johnathan A, Muangprom Amorntip
Abstract excerpt
The orosomucoids (ORM) are ER-resisdent polypeptides encoded by ORM and ORMDL (ORM-like) genes. In humans, ORMDL3 was reported as genetic risk factor associated to asthma. In yeast, ORM proteins act as negative regulators of sphingolipid synthesis. Sphingolipids are important molecules regulating several processes including stress responses and apoptosis. However, the function of ORM/ORMDL genes in plants has not...
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