Article
Polymorphism of interleukin-1β and interleukin-1 receptor antagonist genes in children with autism spectrum disorders.
Progress in neuro-psychopharmacology & biological psychiatry - 20 Dec 2020
Saad Khaled, Abdallah Alam-Eldin M, Abdel-Rahman Ahmed A, Al-Atram Abdulrahman A, Abdel-Raheem Yasser F, Gad Eman Fathallah, Abo-Elela Mohamed Gamil M, Elserogy Yasser M, Elhoufey Amira, Nigm Dalia A, Nagiub Abdelsalam Eman M, Alruwaili Thamer A M
Abstract excerpt
In this study, we first investigated interleukin-1 beta (IL-1β) and IL-1 receptor antagonist (IL-1RA) levels in a cohort of Egyptian children with autism spectrum disorder (ASD) and in healthy controls. Second, we examined the single-nucleotide polymorphisms (SNPs) at positions -31 and - 511 of the IL-1β gene promoter and IL1RA and assessed the association between IL1B and IL1RA polymorphisms with ASD. We...
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