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EFFECT OF ELEXACAFTOR/TEZACAFTOR/IVACAFTOR ON ANNUAL RATE OF LUNG FUNCTION DECLINE IN PEOPLE WITH CYSTIC FIBROSIS.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 May 2023

Lee Tim, Sawicki Gregory S, Altenburg Josje, Millar Stefanie J, Geiger Jessica Morlando, Jennings Mark T, Lou Yiyue, McGarry Lisa J, Van Brunt Kate, Linnemann Rachel W

Abstract excerpt

Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was shown to be safe and efficacious in people with cystic fibrosis (CF) with ≥ 1 F508del-CFTR allele in Phase 3 clinical trials. ELX/TEZ/IVA treatment led to improved lung function, with increases in percent predicted forced expiratory volume in 1 second (ppFEV1) and Cystic Fibrosis Questionnaire-Revised respiratory domain score. Here, we evaluated the impact of...

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PMID: 36581485
DOI: 10.1016/j.jcf.2022.12.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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