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Article

Real-life initiation of lumacaftor/ivacaftor combination in adults with cystic fibrosis homozygous for the Phe508del CFTR mutation and severe lung disease.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 May 2017

Hubert Dominique, Chiron Raphaël, Camara Boubou, Grenet Dominique, Prévotat Anne, Bassinet Laurence, Dominique Stéphane, Rault Gilles, Macey Julie, Honoré Isabelle, Kanaan Reem, Leroy Sylvie, Desmazes Dufeu Nadine, Burgel Pierre-Régis

Abstract excerpt

OBJECTIVE: To investigate the short-term adverse events and effectiveness of lumacaftor/ivacaftor combination treatment in adults with cystic fibrosis (CF) and severe lung disease in a real life setting. METHODS: A multicentre observational study investigated adverse events, treatment discontinuation, FEV1 and body mass index (BMI) one month and three months after lumacaftor/ivacaftor initiation in adults with CF...

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Identifiers

PMID: 28325531
DOI: 10.1016/j.jcf.2017.03.003

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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