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Article

Endothelial Dysfunction May Link Interatrial Septal Abnormalities and MTHFR-Inherited Defects to Cryptogenic Stroke Predisposition.

Biomolecules - 4 Jun 2020

Sgarra Luca, Bortone Alessandro Santo, Potenza Maria Assunta, Nacci Carmela, De Salvia Maria Antonietta, Acquaviva Tommaso, De Cillis Emanuela, Ciccone Marco Matteo, Grimaldi Massimo, Montagnani Monica

Abstract excerpt

We explored the significance of the L-Arginine/asymmetric dimethylarginine (L-Arg/ADMA) ratio as a biomarker of endothelial dysfunction in stroke patients. To this aim, we evaluated the correlation, in terms of severity, between the degree of endothelial dysfunction (by L-Arg/ADMA ratio), the methylene tetrahydrofolate reductase (MTHFR) genotype, and the interatrial septum (IAS) phenotype in subject with a...

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Identifiers

PMID: 32512924
DOI: 10.3390/biom10060861
PMCID: PMC7355772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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