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Article

Osteoprotegerin gene polymorphisms and otosclerosis: an additional genetic association study, multilocus interaction and meta-analysis.

BMC medical genetics - 3 Jun 2020

Bouzid Amal, Tekari Adel, Jbeli Fida, Chakroun Amine, Hansdah Kirtal, Souissi Amal, Singh Neha, Mosrati Mohamed Ali, Achour Imen, Ghorbel Abdelmonem, Charfeddine Ilhem, Ramchander Puppala Venkat, Masmoudi Saber

Abstract excerpt

BACKGROUND: Otosclerosis (OTSC) is among the most common causes of a late-onset hearing loss in adults and is characterized by an abnormal bone growth in the otic capsule. Alteration in the osteoprotegerin (OPG) expression has been suggested in the implication of OTSC pathogenesis. METHODS: A case-control association study of rs2228568, rs7844539, rs3102734 and rs2073618 single nucleotide polymorphisms (SNPs) in...

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Share to Epistasis, Genetic
Share to Genetic Loci
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Identifiers

PMID: 32493243
DOI: 10.1186/s12881-020-01036-8
PMCID: PMC7268516

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