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Article

Genetic variants in RELN are associated with otosclerosis in a non-European population from Tunisia.

Annals of human genetics - 1 Sept 2010

Khalfallah Ayda, Schrauwen Isabelle, Mnaja Malek, Fransen Erik, Lahmar Imed, Ealy Megan, Dhouib Leila, Ayadi Hammadi, Charfedine Ilhem, Driss Nabil, Ghorbel Abdelmonem, Smith Richard J H, Masmoudi Saber, Van Camp Guy

Abstract excerpt

Otosclerosis is a common form of conductive hearing loss, caused by an abnormal bone remodelling in the otic capsule. Both environmental and genetic factors have been implicated in the etiology of this disease. A recent genome wide association study identified two regions associated with otosclerosis, one on chr7q22.1, located in the RELN gene, and one on chr11q13.1. A second study in four European populations...

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Share to Cell Adhesion Molecules, Neuronal
Share to Chromosomes, Human, Pair 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20642811
DOI: 10.1111/j.1469-1809.2010.00595.x

Genes

RELN

Provenance

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Genetic variants in RELN are associated with otosclerosis in a non-European population from Tunisia.PMID 20642811Read ↗

Genetic variants in the RELN gene are associated with otosclerosis in multiple European populations.Semantic proximity Read ↗

A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis.Semantic proximity Read ↗

The risks of RELN polymorphisms and its expression in the development of otosclerosis.Semantic proximity Read ↗

Genome-wide Screen of Otosclerosis in Population Biobanks: 18 Loci and Shared Heritability with Skeletal StructureSemantic proximity Read ↗

Genome-wide screen of otosclerosis in population biobanks: 27 loci and shared associations with skeletal structure.Semantic proximity Read ↗

Clinical and genetic analysis of two Tunisian otosclerosis families.Semantic proximity Read ↗

A new locus for otosclerosis, OTSC8, maps to the pericentromeric region of chromosome 9.Semantic proximity Read ↗

Evidence of distinct RELN and TGFB1 genetic associations in familial and non-familial otosclerosis in a British population.Semantic proximity Read ↗

Osteoprotegerin gene polymorphisms and otosclerosis: an additional genetic association study, multilocus interaction and meta-analysis.Semantic proximity Read ↗

The etiology of otosclerosis: a combination of genes and environment.Semantic proximity Read ↗

Osteoprotegerin gene polymorphisms and otosclerosis: an additional genetic association study, multilocus interaction and meta-analysisSemantic proximity Read ↗

The rs39335 polymorphism of the RELN gene is not associated with otosclerosis in a southern Italian population.Semantic proximity Read ↗

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