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Article

A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis.

American journal of human genetics - 1 Mar 2009

Schrauwen Isabelle, Ealy Megan, Huentelman Matthew J, Thys Melissa, Homer Nils, Vanderstraeten Kathleen, Fransen Erik, Corneveaux Jason J, Craig David W, Claustres Mireille, Cremers Cor W R J, Dhooge Ingeborg, Van de Heyning Paul, Vincent Robert, Offeciers Erwin, Smith Richard J H, Van Camp Guy

Abstract excerpt

Otosclerosis is a common form of progressive hearing loss, characterized by abnormal bone remodeling in the otic capsule. The etiology of the disease is largely unknown, and both environmental and genetic factors have been implicated. To identify genetic factors involved in otosclerosis, we used a case-control discovery group to complete a genome-wide association (GWA) study with 555,000 single-nucleotide...

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Topics

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Share to Cell Adhesion Molecules, Neuronal
Share to Ear, Inner

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Matrix Proteins

Share to Genome, Human

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Source

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Identifiers

PMID: 19230858
DOI: 10.1016/j.ajhg.2009.01.023
PMCID: PMC2667982

Genes

RELN

Provenance

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis.PMID 19230858Read ↗

Genetic variants in the RELN gene are associated with otosclerosis in multiple European populations.Semantic proximity Read ↗

Genetic variants in RELN are associated with otosclerosis in a non-European population from Tunisia.Semantic proximity Read ↗

Genome-wide screen of otosclerosis in population biobanks: 27 loci and shared associations with skeletal structure.Semantic proximity Read ↗

Genome-wide Screen of Otosclerosis in Population Biobanks: 18 Loci and Shared Heritability with Skeletal StructureSemantic proximity Read ↗

The risks of RELN polymorphisms and its expression in the development of otosclerosis.Semantic proximity Read ↗

Osteoprotegerin gene polymorphisms and otosclerosis: an additional genetic association study, multilocus interaction and meta-analysis.Semantic proximity Read ↗

Evidence of distinct RELN and TGFB1 genetic associations in familial and non-familial otosclerosis in a British population.Semantic proximity Read ↗

Genetic association analysis in a clinically and histologically confirmed otosclerosis population confirms association with the TGFB1 gene but suggests an association of the RELN gene with a clinically indistinguishable otosclerosis-like phenotype.Semantic proximity Read ↗

Analysis of the RELN gene as a genetic risk factor for autism.Semantic proximity Read ↗

Controversies in RELN/reelin expression in otosclerosis.Semantic proximity Read ↗

Osteoprotegerin gene polymorphisms and otosclerosis: an additional genetic association study, multilocus interaction and meta-analysisSemantic proximity Read ↗

The etiology of otosclerosis: a combination of genes and environment.Semantic proximity Read ↗

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