Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Propionic acid induces dendritic spine loss by MAPK/ERK signaling and dysregulation of autophagic flux.

Molecular brain - 2 Jun 2020

Choi Hyosun, Kim In Sik, Mun Ji Young

Abstract excerpt

Propionic acid (PPA) is a short-chain fatty acid that is an important mediator of cellular metabolism. It is also a by-product of human gut enterobacteria and a common food preservative. A recent study found that rats administered with PPA showed autistic-like behaviors like restricted interest, impaired social behavior, and impaired reversal in a T-maze task. This study aimed to identify a link between PPA and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagosomes
Share to Autophagy
Share to Dendritic Spines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Flavonoids

Share to Lysosomes

Share to MAP Kinase Signaling System

Share to Propionates

Source

Open in PubMed Open full text

Identifiers

PMID: 32487196
DOI: 10.1186/s13041-020-00626-0
PMCID: PMC7268420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Propionic acid induces dendritic spine loss by MAPK/ERK signaling and dysregulation of autophagic flux.PMID 32487196Read ↗

Propionic acid induces dendritic spine loss by MAPK/ERK signaling and dysregulation of autophagic fluxSemantic proximity Read ↗

Lowering Propionic Acid Levels by Regulating Gut Microbiota with Ursodeoxycholic Acid Appears to Regress Autism Symptoms: An Animal StudySemantic proximity Read ↗

Enteric short-chain fatty acids: microbial messengers of metabolism, mitochondria, and mind: implications in autism spectrum disordersSemantic proximity Read ↗

The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse modelSemantic proximity Read ↗

Postnatal propionic acid exposure disrupts hippocampal agmatine homeostasis leading to social deficits and cognitive impairment in autism spectrum disorder-like phenotype in rats.Semantic proximity Read ↗

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defectsSemantic proximity Read ↗

Correlative Light and Transmission Electron Microscopy Showed Details of Mitophagy by Mitochondria Quality Control in Propionic Acid Treated SH-SY5Y CellSemantic proximity Read ↗

Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiomeSemantic proximity Read ↗

The Ketogenic Diet Metabolite β-Hydroxybutyrate Promotes Mitochondrial Elongation via Deacetylation in HeLa Cells and Improves Autism-like Behavior in ZebrafishSemantic proximity Read ↗

4-hydroxyisoleucine mediated IGF-1/GLP-1 signalling activation prevents propionic acid-induced autism-like behavioural phenotypes and neurochemical defects in experimental rats.Semantic proximity Read ↗

GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABA A receptor trafficking and social behaviorSemantic proximity Read ↗

Ketogenic diet improves behaviors in a maternal immune activation model of autism spectrum disorderSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.