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Article

Abnormal processing of IL-1β in NLRP7-mutated monocytes in hydatidiform mole patients.

Clinical and experimental immunology - 1 Oct 2020

Zhang P, Zhu X, Yu X, Huang B, Jiang T, Zhang X, Yang H, Qian J

Abstract excerpt

NOD-like receptor pyrin 7 (NLRP7) has been identified as the major gene responsible for the recurrent hydatidiform mole (RHM). The immunological role of NLRP7 mutation in HM patients has not been conclusively demonstrated. Hence, we aim to demonstrate this role in our study. We followed 12 new patients with NLRP7 non-synonymous variations (NSVs) from date to date. Peripheral blood mononuclear cells (PBMCs) were...

Topics

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Adaptor Proteins, Signal Transducing
Follow-Up Studies
HEK293 Cells
Hydatidiform Mole
Interleukin-1beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocytes, Mononuclear

Neoplasm Proteins

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Open in PubMed Open full text

Identifiers

PMID: 32484253
DOI: 10.1111/cei.13472
PMCID: PMC7488120

Genes

NLRP7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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