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Picornavirus VP3 protein induces autophagy through the TP53-BAD-BAX axis to promote viral replication

16 May 2024

Abstract excerpt

Macroautophagy/autophagy and apoptosis are pivotal interconnected host cell responses to viral infection, including picornaviruses. Here, the VP3 proteins of picornaviruses were determined to trigger autophagy, with the autophagic flux being triggered by the TP53-BAD-BAX axis. Using foot-and-mouth disease virus (FMDV) as a model system, we unraveled a novel mechanism of how picornavirus hijacks autophagy to...

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PMID: 38752369
DOI: 10.1080/15548627.2024.2350270

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