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Article

Sox9b is a mediator of retinoic acid signaling restricting endocrine progenitor differentiation.

Developmental biology - 1 Oct 2016

Huang Wei, Beer Rebecca L, Delaspre Fabien, Wang Guangliang, Edelman Hannah E, Park Hyewon, Azuma Mizuki, Parsons Michael J

Abstract excerpt

Centroacinar cells (CACs) are ductal Notch-responsive progenitors that in the larval zebrafish pancreas differentiate to form new islets and ultimately contribute to the majority of the adult endocrine mass. Uncovering the mechanisms regulating CAC differentiation will facilitate understanding how insulin-producing β cells are formed. Previously we reported retinoic acid (RA) signaling and Notch signaling both...

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Source

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Identifiers

PMID: 27565026
DOI: 10.1016/j.ydbio.2016.08.019
PMCID: PMC5031550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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