Article
Interleukin 6 gene polymorphisms are associated with systemic lupus erythematosus in Koreans.
The Journal of rheumatology - 1 Nov 2010
Jeon Ja-Young, Kim Hyoun-Ah, Kim Seung-Hyun, Park Hae-Sim, Suh Chang-Hee
Abstract excerpt
OBJECTIVE: Interleukin 6 (IL-6) gene polymorphisms are known to play a role in chronic inflammatory disorders. We searched for polymorphisms in the IL-6 gene and described their pathogenic role in Korean patients with systemic lupus erythematosus (SLE). METHODS: Genomic DNA was extracted from 151 patients with SLE and 151 controls, and about 1.4 kb-sized IL-6 genes located between promoter region and exon 2...
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