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Genomic analysis of the natural history of attention-deficit/hyperactivity disorder using Neanderthal and ancient Homo sapiens samples.

Scientific reports - 25 May 2020

Esteller-Cucala Paula, Maceda Iago, Børglum Anders D, Demontis Ditte, Faraone Stephen V, Cormand Bru, Lao Oscar

Abstract excerpt

Attention-deficit/hyperactivity disorder (ADHD) is an impairing neurodevelopmental condition highly prevalent in current populations. Several hypotheses have been proposed to explain this paradox, mainly in the context of the Paleolithic versus Neolithic cultural shift but especially within the framework of the mismatch theory. This theory elaborates on how a particular trait once favoured in an ancient...

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PMID: 32451437
DOI: 10.1038/s41598-020-65322-4
PMCID: PMC7248073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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