Article
Reciprocal integrin/integrin antagonism through kindlin-2 and Rho GTPases regulates cell cohesion and collective migration.
Matrix biology : journal of the International Society for Matrix Biology - 1 Nov 2020
van der Bijl Ivo, Nawaz Kalim, Kazlauskaite Ugne, van Stalborch Anne-Marieke, Tol Simon, Jimenez Orgaz Ana, van den Bout Iman, Reinhard Nathalie R, Sonnenberg Arnoud, Margadant Coert
Abstract excerpt
Collective cell behaviour during embryogenesis and tissue repair requires the coordination of intercellular junctions, cytoskeleton-dependent shape changes controlled by Rho GTPases, and integrin-dependent cell-matrix adhesion. Many different integrins are simultaneously expressed during wound healing, embryonic development, and sprouting angiogenesis, suggesting that there is extensive integrin/integrin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.