Agonist of RORA Attenuates Nonalcoholic Fatty Liver Progression in Mice via Up-regulation of MicroRNA 122.

doi:10.1053/j.gastro.2020.05.056

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Article

Agonist of RORA Attenuates Nonalcoholic Fatty Liver Progression in Mice via Up-regulation of MicroRNA 122.

Gastroenterology - 1 Sept 2020

Chai Chofit, Cox Bryan, Yaish Dayana, Gross Devora, Rosenberg Nofar, Amblard Franck, Shemuelian Zohar, Gefen Maytal, Korach Amit, Tirosh Oren, Lanton Tali, Link Henrike, Tam Joseph, Permyakova Anna, Ozhan Gunes, Citrin Jonathan, Liao Haixing, Tannous Mirna, Hahn Michal, Axelrod Jonathan, Arretxe Enara, Alonso Cristina, Martinez-Arranz Ibon, Betés Pablo Ortiz, Safadi Rifaat, Salhab Ahmad, Amer Johnny, Tber Zahira, Mengshetti Seema, Giladi Hilla, Schinazi Raymond F, Galun Eithan

Abstract excerpt

BACKGROUND & AIMS: Development of nonalcoholic steatohepatitis (NASH) is associated with reductions in hepatic microRNA122 (MIR122); the RAR related orphan receptor A (RORA) promotes expression of MIR122. Increasing expression of RORA in livers of mice increases expression of MIR122 and reduces lipotoxicity. We investigated the effects of a RORA agonist in mouse models of NASH. METHODS: We screened a chemical...

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PMID: 32450149
DOI: 10.1053/j.gastro.2020.05.056
PMCID: PMC7722250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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