Article
Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers.
Nature communications - 21 May 2020
Sfakianos John P, Daza Jorge, Hu Yang, Anastos Harry, Bryant Geoffrey, Bareja Rohan, Badani Ketan K, Galsky Matthew D, Elemento Olivier, Faltas Bishoy M, Mulholland David J
Abstract excerpt
Tumor heterogeneity is common in cancer, however recent studies have applied single gene expression signatures to classify bladder cancers into distinct subtypes. Such stratification assumes that a predominant transcriptomic signature is sufficient to predict progression kinetics, patient survival and treatment response. We hypothesize that such static classification ignores intra-tumoral heterogeneity and the...
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